When father and scientist Dr. Murray (Chris Pine) goes missing, it’s up to his awkward and angry daughter, Meg (Storm Reid) and her brilliant brother, Charles Wallace (Deric McCabe) to find him. Along the way, they enlist the help of one of Meg’s classmates (Levi Miller) and three magical women- Mrs. Who (Mindy Kaling), Mrs. Whatsit (Reese Witherspoon), and Mrs. Which (Oprah Winfrey).